DZ - The Tojiro ITK steel is pretty reactive compared to some others. It might be an issue in a Pro environment. In my mind, I wouldn't get an Artifex and spend the extra dollars to upgrade the handle. Personally, I'd look to just getting a nicer overall knife (including the handle) in the first place and be done w/it. Not that the Artifex isn't a good knife - it is.
What about the Sakai Takayuki AEB-L Damascus Wa-Gyuto 210: http://www.chefknivestogo.com/satadagy210.html
? Nice, easy to sharpen AEB-L at RC 60, all stainless construction, nice grinds, thin, light, nice profile, etc.
The Kohetsu 210 Gyuto would be an excellent choice as well - I think Mark has more arriving soon.
Another nice option is the Tanaka Sekiso Damascus 210 Gyuto - not a laser, but pretty light and a great performer. Fully reactive blade.
The Moritaka Supreme Gyuto's are really nice as well. Thin, light, AS core, nice Yew handles. I have the Santoku 170 w/the new handle and is a super performer.
What's your price range, including a possible handle upgrade?